The brain is god’s territory, and only geniuses with god’s hands reach out to touch it. Elite surgeons make countless sacrifices to acquire the best skills in their field and obtain the most coveted title given only to the finest: Top Knife.


Even though renowned brain surgeon Yoko Miyama is treated like an empress at the Tohto General Hospital, something has been stressing her out lately. Chief of brain surgery Takao Imadegawa assigned three new doctors under her supervision against her wishes. Reporting to her will be Kengo Kuroiwa, known as "The World's Kuroiwa" for his prowess but also a notorious womanizer, Takuma Nishigori, a surgery and catheter two-way genius who prefers doing operations over eating, and Sachiko Kozukue, a confident intern who graduated at the top of her class but doesn't realize her job performance is below satisfactory.

Not long after starting her new job, Sachiko is suddenly faced with an emergency. Unsure what to do, she freezes but Yoko shows up to save the patient with her on-point decision-making and marvelous techniques. One wrong slice into the brain and there's no going back. That's why the skills of the lead surgeon are everything. Yoko can't hide her irritation at Sachiko, who she feels is useless at the job. What's more, the nurses are predicting that "Empress Yoko" will clash with Kuroiwa and Nishigori, who are both Top Knife surgeons.

Even though they're blessed with world-class skills and prestige, there's something awkward and contradictory about these doctors. Just what did they sacrifice to learn how to save people?!

This is the ultimate human drama about surgeons who handle the mystery that is the brain on a daily basis and are constantly forced to ponder the meaning of life, feelings, and the brain. Follow these geniuses as they go through pains, struggles, and hope in "Top Knife."

A month after Crows ZERO II, a new school year is beginning at Suzuran High. That means the start of another long uphill battle among new seniors for supremacy of the school. Gora seems closest to king of the hill, but his closely contested by rivals, Tetsuji Takagi, Satoshi Terajima and his 5-man gang, and the plucky Kenichi Ogisu. But the arrival of 2 new boys threatens to completely alter the power balance at Suzuran: 3rd year transfer student, Kazeo Kaburagi, who lives as he pleases and shows no interest in the top spot, and freshman, Ryohei Kagami, who likes to fight with instinctive abandon. Gradually, these two unconnected and opposite characters are drawn toward each other and into the center of Suzuran's most epic battle ever.


클로우즈 제로II로부터 한달후. 신학기를 맞은 스즈란고교에서는 공석이 된 정점의 자리를 노리고 3학년생들이 자신의 이름을 건다. 정점의 자리에 가장 가까운 남자 고라 토오루, 그와 라이벌이 될 다카기 테쓰지, 5명을 통솔하는 데라시마 사토시, 경박하고 이성을 잃곤 하는 오기스 켄이치. 하지만 두남자의 등장으로 스즈란 세력은 크게 변한다.「자유롭게 살기 위해」라며 정점싸움에 관심을 보이지 않는 3학
년 전학생 가부라기 센푸오와 본능에 충실하며 날뛰는 1학년 가가미 료헤이. 전혀 대조적인 두사람이 드디어 스즈란사상최대의 싸움의 중심인물이 되어 간다.


漂ノ男子漢(熱血高校)第二集的一個月後迎接新年度的玲蘭高校之頂點空位正被大家虎視眈眈著。新的三年級生中離頂
點最近的男人們是「強羅徹」，他的競爭對手「高木哲次」，統帥五人軍團的「寺島聰司」，和假裝得意忘形容易生氣的「小岐須健一」。但就在兩個新角色出現後玲蘭的勢力版圖頓時有了大變動。一個三年級轉學生「鏑木旋風雄」和本能性喜歡打架的暴力一年級生「加賀美遼平」，這兩個沒有交集個性成正比的人將會成為玲蘭史上最大抗爭的中心人物。